Massimo Mantegazza
CountryFrance
Society affiliation Société des Neurosciences
ORCID ID 0000-0002-1070-7929
Position Principal Investigator/Group Leader
University/Organisation Institut de Pharmacologie Moléculaire et Cellulaire (IPMC)
Domain Other Brain Diseases, Ischemia, Stroke, Injury
Sub domains Action potentials Epilepsy Ion channels
Lab description
We are interested in how ion channels shape neuronal functions (in particular excitability), in how they are modulated or blocked by drugs and toxins and in how their modifications (e.g. mutations) cause pathologies, trying to disclose the complex responses produced by the initial dysfunction. A major focus are voltage gated Na+ (Nav) channels and their involvement in the pathophysiology of epilepsy, migraine and neuro-developmental disorders . We also develop innovative strategies for the treatment of pathological cellular excitability.