PhD position in cellular neuroscience in Cologne

The laboratory of Prof. Natalia Kononenko at the University of Cologne (Medical Faculty & CECAD Excellence Cluster) is looking for a highly motivated PhD candidate to investigate the role of the endocytosis in Purkinje cells and the impact of its deletion on brain-wide motor circuits (see Tolve et al., Cell Reports, 2025). This project is part of CRC1451 (https://www.crc1451.uni-koeln.de/) and involves advanced mouse models, rabies tracing, chemogenetics, multi-omics, super-resolution microscopy, miniscope Ca2+ imaging, offering an excellent opportunity to engage in cutting-edge neurobiology research.

• Activities and responsibilities
  Conduct research in mouse models to investigate how inhibition of endocytosis in Purkinje cells affects information processing in the thalamo-cortical network.
  Perform experiments in cerebellar organotypic slice cultures using GCaMP6-based calcium imaging and chemogenetics.
  Perform stereotactic surgeries and use chemogenetics to manipulate brain motor circuits.
  Conduct biochemical assays, such as pull-down experiments and proteomic analyses.
  Maintain accurate lab records and clearly present findings in meetings.
• Qualification profile
  Master’s degree in Neuroscience, Cell Biology, or Biochemistry (with very good to excellent grades).
  Experience with techniques such as rodent models of neurodegeneration, primary cell culture, immunohistochemistry, microscopy, image analysis, and biochemical assays.
  Strong motivation to advance research in neurodegenerative diseases.
  Proficiency in English.
  Excellent organizational skills, a proactive attitude, enthusiasm, and a willingness to learn.
• We offer
  All social benefits provided by working for the public service: e.g. an annual bonus, payment of benefits.
• Start Date and Location: April/May 2025, in Cologne, Germany.
• Application Process:Please submit a single PDF containing the following: a motivation letter, a CV with contact details for 2-3 references, a short (300-word) summary of a recent publication from Kononenko’s lab, including a research outlook and a proposal for future research on the topic.