Job ID: 121707

Research Associate in Circadian Biology

Position: Post-doctoral Position

Deadline: 24 April 2025

Contract Length: 1 year initially. Further extensions are expected on existing lab funds and/or fellowship applications.

City: London

Country: United Kingdom

Institution: Imperial College London

Department: Brain Sciences

Description:

Project: Leveraging circadian clocks to prevent Alzheimer’s disease

In this project, you will develop new molecular tools modifying circadian pathways to prevent/ delay Alzheimer’s disease. This project stems from newly established mouse models and clock molecular targets identified in the Brancaccio Lab. You will perform viral delivery of gene therapy viral vectors, behavioural assessment of sleep-wake cycles and cognition, multiplexed live imaging in brain tissue, combinatorial intersectional genetics, and multivariate statistical analysis of time series to validate new chronotherapeutic interventions in Alzheimer’s disease. Further experience with analyses of large ‘OMICS dataset and advanced molecular biology tools in addition to stereotaxic brain surgery and live imaging will be an element of significant strength for this position. Previous knowledge of circadian biology is desirable but not strictly necessary.