Job ID: 120485

ERC- funded Post-doc position – long-lived chromatin RNAs dependent chromatin regulation

Position: Post-doctoral Position

Deadline: 1 December 2024

Employment Start Date: 1 January 2025

City: Erlangen

Country: Germany

Institution: Friedrich-Alexander Universität Erlangen-Nürnberg

Department: Laboratory of Neural Epigenomics, Institute of Medical Physics, Faculty of Medicine

Description:

The Toda lab (https://todalab.com/home) at the Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)/Max-Planck-Zentrum für Physik und Medizin (MPZ-PM) is looking for a postdoctoral fellow for the ERC-funded project:  Long-lived RNA in chromatin regulation

Aging is one of the most critical risk factors for neurological diseases. However, the biological links between physiological aging and pathological development are still largely unknown. The Toda lab at FAU/MPZ-PM aims to elucidate this link between the fundamental mechanism underlying the long-term maintenance of neural identity/plasticity and effects of aging on it.

In particular, we are trying to understand the role of chromatin-associated long-lived RNAs in the long-term maintenance of epigenetic landscape (https://pubmed.ncbi.nlm.nih.gov/38574132/). We combine several approaches ranging from molecular biology, cell biology, epigenomics, and computational biology in rodent models. The project will focus on recently identified long-lived RNAs in the brain. Combining epigenomic and computational approaches, a post-doc is expected to investigate how long-lived RNAs regulate cell type-specific epigenetic landscapes.

Erlangen is an international university city with a vibrant environment in the middle of Bavaria. New research direction in the combination between neurosciences and biophysics are emerging in the recently established MPZ-PM. The lab is located at the MPZ-PM. The Toda lab is addressing the fundamental question of brain aging using epigenomic, biochemical, and neurobiological approaches.

Your profile

  • Applicants must have a Ph.D. or expect to obtain a Ph.D, and should have experience relevant to our research interests such as epigenomics, RNA biology and computational biology.
  • Capable to work independently within a collaborative environment
  • Previous experiences in cell biology and epigenomics (ex. Cell culture, ChIP-seq/ eCLIP/ HiC/NGS data analysis) is essential.
  • Applicants should have at least one peer-reviewed first author publication in international journals
  • Lab language is English

Documents required for application

  1. Curriculum Vitae
  2. Letter of motivation including i) past accomplishments, ii) project plans, and iii) future goals
  3. Contact details of two references

Please submit your application to tomohisa.toda@fau.de

We will review applications on a rolling-basis.