Job ID: 119666

Post-doctoral researcher DBS – LysoPDCalcium

Position: Post-doctoral Position

Deadline: 18 August 2024

Employment Start Date: 1 October 2024

Contract Length: 1 year, renewable

City: Paris

Country: France

Institution: Institut du Cerveau / Paris Brain Institute

Department:

Description:

context

DBS: from genetic mutations to motor circuit dysfunctions & recovery

DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project’s goal is to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects – Collaborative, interdisciplinary, innovative & transformative

As part of DBS, we will implement the hiring of post-docs each dedicated to one collective interest project to be co-supervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in the field that they have not received training on yet, either genetics, cellular physiology, imaging, optogenetics, behavior or modelling.

We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.

In the LysoPDCalcium project, the candidate will be hosted by the teams of Jaime de Juan-Sanz and Dafni Hadjieconomou. This project aims to address the urgent need to understand lysosomal Ca2+ dysregulation in Parkinson’s Disease (PD), an area that is critical yet poorly explored. Our proposal aims to develop LysoCaMPs, innovative optical tools for the direct measurement of lysosomal Ca2+, which will provide crucial insights into synaptic physiology and neuronal activity. This project will apply these tools both in iPSC-derived neurons and in vivo models using Drosophila, to uncover the mechanisms by which Ca2+-mediated adjustments of mitochondrial metabolism support neurotransmission and contribute to PD pathology.

Missions

Transgenic Fly Generation, extensive experience working with Drosophila melanogaster
Lysosomal Targeting, Chemical Ligand Delivery
In Vivo Imaging
Lysosomal Ca2+ Analysis
Drosophila Behavioral Assays
Data Analysis
Collaborative Research
Plan experiments, collect data, and analyze results.
Organize tasks and participate in DBS project discussions.

Conditions

Remuneration scale: 35 000 – 45 000 € (gross annual)
Fixed-term contract (CDD), renewable

PROFILE

know-how

Capable of supervising students.
Good autonomy within planning experimental protocols, proactive, team player.
Rigorous with data analysis.
Ability to work in a project-based mode.
Proficient reading, writing, and conversational skills in scientific English (required).

knowledge

Drosophila Genetics
Molecular Biology
Brain-Gut Axis in Drosophila
Behavioral Assays in Drosophila
Rigorous, organized, and swift scientific writing with dexterity, conciseness and precision.
Proficiency in the use of software to electrophysiological and/or imaging data including python, FIJI, etc.
Ability to summarize results.
PhD in Neuroscience or associated disciplines.

Soft skills

Sense of responsibility and collective interest.
Integrity, honesty, and loyalty.
Team spirit and solidarity, socially engaged and invested in the team’s well-being.
Proactivity, motivation, and curiosity.
Desire to share knowledge and train others in good scientific practices that respect individuals.
Scientific rigor, attention to detail, strong organizational skills, conciseness, precision, and discipline.

Please send your CV, letter of motivation and 2 reference letters with contact details to jaime.dejuansanz@icm-institute.org, dafni.hadjieconomou@icm-institute.org and joana.guedes@icm-institute.org with the subject: “DBS CIP LysoPDCalcium Post-doc (M/F)”

https://institutducerveau-icm.org/wp-content/uploads/2024/06/dbs_cip-lysopdcalcium_recruitment_icm-en.pdf