Job ID: 118783
Ph.D. student in neurotransmitter sensor engineering
Position: Ph.D. Student
Deadline: 31 July 2024
Employment Start Date: 1 September 2024
Contract Length: Multiple years with annual renewal
City: Zurich
Country: Switzerland
Institution: University of Zurich
Department: Institute of Pharmacology and Toxicology
Description:
The lab has strong expertise in building genetically-encoded fluorescent sensors that allow the direct visualization of G protein-coupled receptor (GPCR) activation by ligands with very high spatial and temporal resolution in living animals (mice). This new project will leverage on protein engineering, directed evolution of sensors in mammalian cell lines, as well as advanced ex vivo and in vivo imaging modalities that we have in the lab to engineer novel chemigenetic indicators for imaging neuromodulators. We are looking for a motivated and hard-working student with good prior experience in molecular cloning and cellular imaging (confocal microscopy) and a good understanding of membrane receptor biology for this exciting project.