Job ID: 117756
Postdoctoral position in Systems Neuroscience
Position: Post-doctoral Position
Deadline: 1 March 2024
City: Stockholm
Country: Sweden
Institution: Karolinska Instiutet
Department: Department of Neuroscience
Description:
Postdoctoral position in Systems Neuroscience
We are seeking a curious and highly motivated postdoctoral researcher to join the Calvigioni Research Team at the Department of Neuroscience, Karolinska Institute in Stockholm, Sweden.
THE RESEARCH TEAM
The research focus of the team is the study of the neurobiology of stress sensitivity, anxiety disorders, stress-induced long-lasting brain states (Calvigioni et al., Nature Neuroscience, 2023), and maladaptive neurodevelopment, with a specific focus on sex differences and critical windows (i.e adolescence). We aim to identify the cellular and molecular state transition in projection-defined and genetically identified sensitive brain network, causal to stress-induced long-lasting disorders, as to the increased sensitivity in women and adolescents.
Our approach, long-term vision, and methodology strive to ultimately uncover how single neurons encode stimuli of emotional valence in vivo in the healthy brain and identify the causality between activity modes/genetic cell states and behavioral transition to anxiety disorders.
YOUR MISSION
The successful candidate will use genetic mouse models, stereotactic surgery, and intersectional viral approaches combined with in vivo behaviors, optogenetics/chemogenetics manipulation, molecular biology, and neuroanatomical analyses, in adult and developing mice.
The project will also involve dissecting the molecular and functional heterogeneity of relevant brain circuits using state-of-the-art single cell molecular (snSEQ, patchSeq) and functional profiling methods (ex-vivo patch-clamp electrophysiology, in vivo fiber photometry and single neuron calcium imaging).
YOUR PROFILE
Previous experience in the study of neuronal circuits in rodent models of stress or development is preferred but not essential. Candidates with experience in anatomical tracing/behavior/electrophysiology and/or imaging techniques will be prioritized. Experience with slice electrophysiology/ in vivo experiments/ neuroendocrinology/ RNA-sequencing and advanced data analysis will be considered and positively evaluated.
A curious mind, positive attitude, high motivation, and analytical approach to independent problem-solving are essential.
The earliest start date is Spring 2024 but can be negotiated when the appropriate candidate is found.
APPLICATION PROCESS
An application must contain the following documents in English:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
- At least 2 letters of reference (with contact details of refence)
The application is to be submitted on the Varbi recruitment system: https://ki.varbi.com/what:job/jobID:699366/