Research Associate – UK Dementia Research Institute

Job summary

Applications are invited for a fully funded Cross-Centre Research Associate in Computational Genomics in the UK Dementia Research Institute. You will lead one or more projects characterising the epigenome of midbrain cell-types for the interpretation of Parkinson’s Disease susceptibility. You will be based at the Imperial College London under the immediate guidance of Dr Alexi Nott (https://nottgroup.com/index.html) to profile the epigenome and chromatin architecture of midbrain cell-types with additional bioinformatics supervision from, and regular residential visits to Prof Caleb Webber’s team (Cardiff University) (https://ukdri.ac.uk/team/calebwebber). You will contribute to the design and analysis of large-scale ‘omics datasets with a primary focus on analysis of the epigenome and chromatin architecture to address major research questions relevant to PD.   The position is available initially for a period of 2 years, with potential for extension.

We are a globally leading multidisciplinary research institute of 800 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at Imperial College London, University College London, the University of Cambridge, Cardiff University, Edinburgh University, and King’s College London.

Please contact Dr Alexi Nott for further discussion about the project and role.

This role is part of the UK Dementia Research Institute at Imperial College London, located in the Department of Brain Sciences. Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:

• Access to a range of cutting-edge technologies.
• An inclusive and collegial working environment.
• Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
• Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities.
• The opportunity to mentor, supervise and teach students.

You will be a motivated and organised researcher, excited by the science we do.

Duties and responsibilities

• • Analysis and visualisation for large scale ‘omics datasets

• • Lead computational projects exploring the transcriptome, epigenome and 3D chromatin architecture of brain cell types

• • Work collaboratively as part of a multidisciplinary research team

• • Demonstrate an aptitude for an organised, methodical approach to your work

Essential requirements

• • Strong programming skills in R, Python, or other coding languages (e.g., C++, Matlab)

• • Experience within a High-Performance Computing environment

• • Research Associate: Hold a PhD (or equivalent) in Computational Biology, Mathematics or a closely related discipline, or equivalent research or industrial experience

Further information

The role is offered full time and fixed term, initially for two years with the potential for extension.

The post is based in the new UK DRI research labs on the White City Campus in West London. You will benefit from an active research (and social) environment in the Department of Brain Sciences, with additional research labs in the Burlington Danes Building on the nearby Hammersmith Campus.

Imperial is one of the UK’s most international universities and welcomes staff from all backgrounds and from all over the world.

Candidates without a PhD awarded will start on the Research Assistant pay scale.

Applicants are encouraged to contact Dr Alexi Nott (a.nott@imperial.ac.uk) for an informal discussion about the project and the role.

For more information about the UK DRI at Imperial, please visit:

http://www.imperial.ac.uk/dementia-research-institute

For information about the Neuroepigenomics Lab, visit the Nott Group:

https://nottgroup.com/

The UK Dementia Research Institute

https://ukdri.ac.uk/

Documents

• JD_Research Associate_ukdr – Final SR.pdf